The story follows Joe, (Cage), a down-on-his-luck truck driver haunted by the memory of his deceased wife and child. He meets Julie (Potente), a spiritually gifted woman who enlists Joe in a desperate effort to find the lost soul of her comatose daughter, Billie (Mitchell). But the spirit of Joe's dead wife Mary proves stronger, possessing the young woman's body and determined to settle her unfinished business with the living.Joe meets a mother who can contact spirits when suffocating. Her daughter is dying when Joe helps the mother spiritually contact the daughter and save her. Unfortunately, the spirit in the daughter's body is now that of Joe's dead wife.